Vayne Runes & Build Guide

A comprehensive guide for Vayne's optimal rune setup in patch 15.4, featuring the highest win rate combinations and matchup data.

Primary Runes (Precision)

• Lethal Tempo (Keystone)
• Triumph
• Legend: Alacrity
• Coup de Grace

Secondary Runes (Resolve)

• Conditioning
• Overgrowth

Current Performance:

• Win Rate: 52.2%
• Pick Rate: 65.3%
• Based on 14,710 matches

Strong Against:

• Mel (60.5%)
• Ziggs (54.7%)
• Kai'Sa (54.4%)
• Ezreal (54.3%)
• Sivir (53.8%)
• Smolder (53.6%)

Best Support Synergies:

• Zyra (57.8%)
• Soraka (56.4%)
• Milio (55.6%)
• Zilean (55.6%)
• Seraphine (54.9%)
• Rakan (54.1%)

Challenging Matchups:

• Nilah (46.4%)
• Yasuo (49.2%)
• Aphelios (49.2%)
• Twitch (49.5%)
• Varus (49.7%)
• Caitlyn (49.8%)

Key Tips:

1. Focus on safe farming early game to scale into mid and late game
2. Aim for three consecutive auto-attacks to maximize W passive damage
3. Use Tumble (Q) defensively in teamfights
4. Position carefully and prioritize survival over aggression

Essential Combos:

• Basic Trading: Auto > Q > Auto
• Full Damage: Auto > Q > E > Auto
• Defensive: E > Q backwards
• Chase: R > Q > Auto > E > Auto

This build and strategy guide is based on current meta data and professional player preferences. Adapt your playstyle according to team composition and matchup specifics.

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