Vayne is a scaling ADC who excels at single-target damage and tank-shredding. Here's the optimal build and strategy for playing her effectively:

Core Build:

• First Item: Blade of The Ruined King
• Boots: Berserker's Greaves
• Core Items: Guinsoo's Rageblade, Terminus, Jak'Sho The Protean, Wit's End

Runes:

• Primary: Lethal Tempo, Triumph, Legend: Alacrity, Coup de Grace
• Secondary: Conditioning, Overgrowth
• Shards: Attack Speed, Adaptive Force, Health Scaling

Summoner Spells:

• Flash
• Barrier

Ability Order: Q → W → E

Key Tips:

• Play safe early game and focus on farming
• Aim for three auto-attacks to proc Silver Bolts (W)
• Position carefully in teamfights, using Q defensively when needed

Strong Against:

• Mel (60.1% WR)
• Ziggs (54.4% WR)
• Kai'Sa (54.3% WR)
• Ezreal (54.2% WR)
• Sivir (53.6% WR)

Weak Against:

• Nilah (45.8% WR)
• Aphelios (49.2% WR)
• Yasuo (49.6% WR)
• Varus (49.6% WR)
• Caitlyn (49.8% WR)

Best Supports:

• Zyra (57.9% WR)
• Soraka (56.8% WR)
• Milio (55.7% WR)
• Zilean (55.7% WR)
• Seraphine (54.6% WR)

This build currently maintains a 55.1% win rate across 8,831 matches in Emerald+ ranking.

Alternative Build Option: Replace Blade of The Ruined King with Kraken Slayer for more raw damage output (54.3% WR over 2,070 matches).

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