Senna Support Rune Guide

The most effective rune setup for Support Senna in patch 14.23 achieves a 52.1% win rate with a 44.6% pick rate across 7,403 matches.

Primary Tree: Resolve

• Keystone: Grasp of the Undying
• Font of Life
• Second Wind
• Revitalize

Secondary Tree: Precision

• Presence of Mind
• Legend: Alacrity

Counter Matchups: Strong Against:

• Swain (62.0% WR)
• Brand (60.0% WR)
• Tahm Kench (57.8% WR)
• Ashe (57.5% WR)
• Sylas (57.4% WR)
• Maokai (56.7% WR)

Weak Against:

• Zoe (41.8% WR)
• Shaco (44.1% WR)
• Neeko (46.5% WR)
• Nami (46.9% WR)
• Lux (47.2% WR)
• Blitzcrank (47.5% WR)

Best ADC Synergies:

• Nilah (61.2% WR)
• Xayah (54.8% WR)
• Jhin (53.6% WR)
• Vayne (53.6% WR)
• Draven (53.6% WR)
• Varus (53.5% WR)

Key Tips:

• Avoid using ultimate (R) mid-combo as it leaves you vulnerable and reduces DPS
• Save E for escape or gank protection rather than combat
• Play aggressively at level 1 to establish lane dominance
• Conserve mana by using E sparingly
• Focus on poking enemies while collecting souls

This optimized rune setup maximizes Senna's support potential while maintaining strong damage output and utility for the team.

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