Mordekaiser's optimal runes in patch 15.4 feature a Precision/Resolve combination, achieving a 50.4% win rate with an 87.9% pick rate across 50,761 matches.

Primary Rune Path (Precision):

• Keystone: Conqueror
• Triumph
• Legend: Alacrity
• Last Stand

Secondary Rune Path (Resolve):

• Second Wind
• Revitalize

Strong Against:

• Malphite (56.1% WR)
• Illaoi (55.3% WR)
• Maokai (54.4% WR)
• Wukong (54.2% WR)
• Dr. Mundo (53.4% WR)
• Poppy (52.9% WR)

Weak Against:

• Cassiopeia (39.3% WR)
• Heimerdinger (44.9% WR)
• Vayne (45.0% WR)
• Singed (45.2% WR)
• Fiora (46.5% WR)
• Warwick (46.6% WR)

Best Jungle Synergies:

• Master Yi (54.0% WR)
• Wukong (53.7% WR)
• Kindred (53.4% WR)
• Jarvan IV (53.3% WR)
• Darius (53.2% WR)
• Rengar (52.9% WR)

Key Tips:

1. Target priority threats with Ultimate (R) in team fights
2. Maximize W shield before trading
3. Wait for ranged champions to use mobility abilities before attempting E

These stats and tips are based on top lane performance data, helping you optimize your Mordekaiser gameplay for maximum effectiveness.

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