Best Karthus Guide - League of Legends Mastery in Patch 15.4.1

Best Karthus Guide - League of Legends Mastery in Patch 15.4.1

By Marcus Chen

February 26, 2025 at 12:27 PM

Karthus is a powerful mage known for his global presence and sustained damage output. His unique passive "Defy Death" allows him to continue casting abilities for 7 seconds after death, making him a constant threat in teamfights.

Core Abilities Overview:

Q - Devastate

  • Creates an explosion after 0.5s delay
  • Deals double damage to isolated targets
  • Primary farming and trading tool
  • Strong level 1 all-in potential

W - Wall of Pain

  • Creates a wall granting vision for 5 seconds
  • Slows enemies passing through
  • Reduces enemy magic resistance by 15%
  • Costs 70 mana (equivalent to 2-3 Q casts)

E - Annihilation

  • Passive: Restores mana on unit kills
  • Active: Deals magic damage every 0.25s
  • Can be toggled on/off
  • Each deactivation deals damage

R - Requiem

  • Global ultimate ability
  • Deals magic damage to all enemy champions

Skill Order Priority:

  1. Q - Devastate (Max first)
  2. E - Annihilation
  3. W - Wall of Pain Ultimate at levels 6, 11, and 16

Early Game Level Order:

  • Level 1: Q
  • Level 2: E
  • Level 3: Q (or E for better mana sustain)
  • Level 4: W (can be delayed to 5 if needed) Standard progression: Q->E->Q->W

Team Composition:

  • Ideal as the sole AP damage source
  • Excels when enemies build minimal magic resistance
  • Strong with CC-heavy supports
  • Effective in AoE team compositions

Key Strengths:

  • Exceptional farming capability
  • Strong level 1 all-in potential
  • Global map pressure with ultimate
  • High sustained damage output
  • Effective even after death

Build Focus:

  • Prioritize AP items with damage-over-time effects
  • Build ability haste for spell rotation
  • Include magic penetration for late game scaling
  • Mana items essential for sustained casting

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