
Best Karthus Guide - League of Legends Mastery in Patch 15.4.1
Karthus is a powerful mage known for his global presence and sustained damage output. His unique passive "Defy Death" allows him to continue casting abilities for 7 seconds after death, making him a constant threat in teamfights.
Core Abilities Overview:
Q - Devastate
- Creates an explosion after 0.5s delay
- Deals double damage to isolated targets
- Primary farming and trading tool
- Strong level 1 all-in potential
W - Wall of Pain
- Creates a wall granting vision for 5 seconds
- Slows enemies passing through
- Reduces enemy magic resistance by 15%
- Costs 70 mana (equivalent to 2-3 Q casts)
E - Annihilation
- Passive: Restores mana on unit kills
- Active: Deals magic damage every 0.25s
- Can be toggled on/off
- Each deactivation deals damage
R - Requiem
- Global ultimate ability
- Deals magic damage to all enemy champions
Skill Order Priority:
- Q - Devastate (Max first)
- E - Annihilation
- W - Wall of Pain Ultimate at levels 6, 11, and 16
Early Game Level Order:
- Level 1: Q
- Level 2: E
- Level 3: Q (or E for better mana sustain)
- Level 4: W (can be delayed to 5 if needed) Standard progression: Q->E->Q->W
Team Composition:
- Ideal as the sole AP damage source
- Excels when enemies build minimal magic resistance
- Strong with CC-heavy supports
- Effective in AoE team compositions
Key Strengths:
- Exceptional farming capability
- Strong level 1 all-in potential
- Global map pressure with ultimate
- High sustained damage output
- Effective even after death
Build Focus:
- Prioritize AP items with damage-over-time effects
- Build ability haste for spell rotation
- Include magic penetration for late game scaling
- Mana items essential for sustained casting