Lissandra's optimal runes focus on Domination/Sorcery, achieving a 50.6% win rate and 52.7% pick rate across 16,073 matches in patch 15.5.

Primary Runes (Domination):

• Keystone: Electrocute
• Taste of Blood
• Grisly Mementos
• Ultimate Hunter

Secondary Runes (Sorcery):

• Axiom Arcanist
• Transcendence

Strong Matchups:

• Karma (58.4% WR)
• Mel (56.1% WR)
• Aurora (54.8% WR)
• Kayle (54.1% WR)
• Galio (54.0% WR)
• Akali (53.9% WR)

Weak Matchups:

• Swain (42.8% WR)
• Anivia (43.8% WR)
• Taliyah (44.6% WR)
• Annie (45.2% WR)
• Vel'Koz (45.6% WR)
• Cassiopeia (46.6% WR)

Best Jungle Synergies:

• Shyvana (56.5% WR)
• Master Yi (56.0% WR)
• Bel'Veth (54.7% WR)
• Briar (53.8% WR)
• Hecarim (53.5% WR)
• Kindred (53.5% WR)

Essential Tips:

1. Position Q to hit both minions and enemy champions
2. Use E for flanking maneuvers in team fights
3. When behind, use abilities to peel for your ADC
4. Ultimate (R) can be used defensively on enemy frontline

Combat Strategy:

• Excel at initiating team fights through flanking
• Focus on wave clear while harassing opponents
• Prioritize protecting carries when playing defensively

This data represents optimal builds and strategies based on high-level play statistics.

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