Vayne Top Runes & Matchups Guide

Optimal Rune Setup Precision (Primary) + Resolve (Secondary)

• Win Rate: 52.2%
• Pick Rate: 52.8%
• Sample Size: 2,014 matches

Keystone: Lethal Tempo Best Precision Runes:

• Triumph
• Legend: Alacrity
• Coup de Grace

Best Resolve Runes:

• Bone Plating
• Overgrowth

Matchup Analysis

Weak Against:

• Nilah (46.3% WR)
• Aphelios (49.1% WR)
• Varus (49.5% WR)
• Yasuo (49.6% WR)
• Twitch (49.8% WR)
• Caitlyn (49.8% WR)

Strong Against:

• Mel (60.3% WR)
• Ziggs (54.4% WR)
• Kai'Sa (54.3% WR)
• Ezreal (54.2% WR)
• Sivir (53.6% WR)
• Jhin (53.4% WR)

Best Support Synergies:

• Zyra (57.9% WR)
• Soraka (56.6% WR)
• Milio (55.7% WR)
• Zilean (55.6% WR)
• Seraphine (54.8% WR)
• Leona (54.4% WR)

Essential Tips

1. Maximize range advantage against melee champions by maintaining maximum attack distance
2. Secure trades by landing three consecutive auto-attacks to proc Silver Bolts (W)
3. Save Tumble (Q) for defensive repositioning in teamfights rather than aggressive plays

This data is based on Patch 15.4 statistics and provides optimal setups for Vayne in the top lane position.

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