Varus's optimal runes combine Precision and Inspiration trees, achieving a 49.6% win rate with a 51.1% pick rate across 69,083 matches in patch 14.23.

Primary Runes (Precision):

• Lethal Tempo (Keystone)
• Triumph
• Legend: Alacrity
• Coup de Grace

Secondary Runes (Inspiration):

• Biscuit Delivery
• Cosmic Insight

Strong Against:

• Kalista (52.5% WR)
• Twitch (52.2% WR)
• Samira (51.5% WR)
• Swain (51.2% WR)
• Kai'Sa (51.0% WR)
• Smolder (50.9% WR)

Weak Against:

• Hwei (45.6% WR)
• Kog'Maw (46.6% WR)
• Seraphine (47.0% WR)
• Ziggs (47.4% WR)
• Sivir (47.4% WR)
• Nilah (47.9% WR)

Best Support Synergies:

• Elise (59.2% WR)
• Galio (54.9% WR)
• Camille (53.9% WR)
• Taric (53.7% WR)
• Shen (53.3% WR)
• Amumu (52.8% WR)

Key Tips:

1. Poke enemies with E and Q before engaging
2. Use Q for harassment and R to catch out-of-position enemies
3. Stay close to your support in late game to avoid assassins

Optimal Combos:

• Q > AA > E for poke
• R > E > Q > AA for all-in
• E > Q > AA for trading
• R > W > Q > E for maximum burst

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