Vayne is a late-game hypercarry ADC who excels at single-target damage and dueling. Here's the optimal build and strategy guide for patch 15.4.

Core Build

• First Item: Blade of the Ruined King
• Boots: Berserker's Greaves
• Core Items: Guinsoo's Rageblade, Terminus

Situational Items

• Jak'Sho, The Protean (vs burst damage)
• Wit's End (vs magic damage)
• Immortal Shieldbow (for survivability)

Recommended Runes

• Primary: Lethal Tempo, Triumph, Legend: Alacrity, Coup de Grace
• Secondary: Conditioning, Overgrowth
• Shards: Attack Speed, Adaptive Force, Health Scaling

Summoner Spells

• Flash
• Barrier

Skill Order Q > W > E > R

Key Tips

• Farm safely early game and scale into late
• Proc Silver Bolts (W) with three consecutive auto-attacks
• Use Tumble (Q) defensively in teamfights
• Position carefully and focus on staying alive

Strong Against

• Mel (60.9% WR)
• Kai'Sa (54.6% WR)
• Ziggs (54.5% WR)
• Ezreal (54.2% WR)

Weak Against

• Nilah (45.6% WR)
• Lucian (49.6% WR)
• Varus (49.7% WR)
• Caitlyn (49.7% WR)

Best Supports

• Zyra (58.5% WR)
• Soraka (56.7% WR)
• Leona (55.4% WR)
• Milio (55.3% WR)

Current patch stats: 55.0% win rate over 8,518 matches in Emerald+ ranking.

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