The Plague Rat assassin excels at surprising enemies with his unique blend of stealth and ranged attacks. Here's a comprehensive guide to mastering Twitch.

Core Abilities Overview

Passive - Deadly Poison

• Applies stacking poison with basic attacks
• Deals true damage per stack for 6 seconds
• Stacks up to 6 times

Q - Ambush

• Grants 10-14 seconds of camouflage
• 30-50% attack speed bonus when revealed
• Cooldown resets when poisoned enemies die

W - Poison Bottle

• Area of effect poison application
• Contaminates ground for 3 seconds
• Slows enemies by 25-45%

E - Contaminate

• Deals physical damage to poisoned targets
• Damage increases with poison stacks
• Key damage ability for trades

R - Fire and Pray

• 6 seconds duration
• +20-40 AD and +300 attack range
• Attacks pierce through targets
• Can critically strike multiple enemies

Optimal Skill Order

1. Level 1: Q (Ambush)
2. Level 2: E (Contaminate)
3. Max Priority: R > E > Q > W

Early Game Strategy

• Start with Q for early pressure or lane control
• Use stealth to set up favorable trades
• Stack poison before using E
• Consider Doran's Ring start versus difficult matchups

Build Path Goals

Primary Stats:

• Attack Damage
• Attack Speed
• Critical Strike
• Armor Penetration
• Life Steal

Core Items:

• Kraken Slayer
• Blade of the Ruined King
• Infinity Edge
• Lord Dominik's Regards

Advanced Tips

• Position creatively with stealth before teamfights
• Use ultimate to maximize damage through enemy frontline
• Time Contaminate with maximum poison stacks
• Reset Q cooldown by securing poisoned kills

Note: The exact numbers and values are subject to change with patches. Currently accurate for Patch 15.4.1.

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