A comprehensive guide to Tryndamere runes for mid lane in patch 14.23, featuring a strong 54.3% win rate setup with 52.4% pick rate across 3,567 matches.

Primary Rune Path: Resolve

• Keystone: Grasp of the Undying
• Demolish
• Second Wind
• Overgrowth

Secondary Rune Path: Precision

• Legend: Alacrity
• Last Stand

Strong Matchups:

• Smolder (65.9% WR)
• Sylas (59.7% WR)
• Yasuo (56.3% WR)
• Garen (54.0% WR)
• Irelia (54.0% WR)
• Dr. Mundo (53.8% WR)

Weak Matchups:

• Zac (41.4% WR)
• Malphite (43.4% WR)
• Singed (45.2% WR)
• Warwick (45.8% WR)
• Darius (46.6% WR)
• Kled (46.6% WR)

Best Jungle Synergies:

• Rek'Sai (54.6% WR)
• Talon (54.2% WR)
• Amumu (53.8% WR)
• Elise (53.8% WR)
• Briar (53.7% WR)
• Skarner (52.9% WR)

Key Tips:

1. Engage in extended trades when your Fury bar is full and enemies are overextended
2. Focus on split pushing and 1v1 duels rather than team fights
3. Play conservatively when your Ultimate (R) is on cooldown

Combat Strategy:

• Prioritize split pushing over team fighting
• Look for favorable trades when Fury is maxed
• Only commit to fights when Ultimate is available

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