First Strike is currently the optimal keystone for Syndra mid lane with a 51.6% win rate in patch 15.6. The most effective rune combination pairs Inspiration primary with Sorcery secondary.

Primary Runes (Inspiration)

• First Strike
• Cash Back
• Triple Tonic
• Jack Of All Trades

Secondary Runes (Sorcery)

• Manaflow Band
• Transcendence

Strong Matchups

• Tristana (62.5% WR)
• Mel (62.2% WR)
• Veigar (60.6% WR)
• Ryze (58.8% WR)
• Talon (58.8% WR)
• Hwei (57.6% WR)

Weak Matchups

• Diana (36.6% WR)
• Kassadin (38.4% WR)
• Anivia (41.7% WR)
• Ekko (43.9% WR)
• LeBlanc (45.4% WR)
• Katarina (45.9% WR)

Best Jungle Synergies

• Darius (57.7% WR)
• Nocturne (57.5% WR)
• Naafiri (53.5% WR)
• Hecarim (52.8% WR)
• Jarvan IV (52.7% WR)
• Xin Zhao (51.5% WR)

Key Tips

1. Poke with Q and W while positioning Dark Spheres for team fights
2. Maximize sphere count before using ultimate for highest damage output
3. Use Dark Spheres in bushes with E for surprise stuns and picks
4. Delay team fights while setting up sphere positions for optimal engagement

Stats based on 3,888 analyzed matches

Related Articles

Previous Articles