An optimized guide to Syndra runes and matchups for Season 15, based on current meta analysis and win rates.

Core Runes Setup

• Primary: Inspiration
• Secondary: Sorcery
• Current Win Rate: 51.6% (based on 44,090 matches)

Key Rune Choices

• Keystone: First Strike
• Inspiration Tree: Cash Back, Triple Tonic, Jack Of All Trades
• Sorcery Tree: Axiom Arcanist, Transcendence

Strong Matchups

• Jayce (56.2% WR)
• Tristana (55.9% WR)
• Mel (55.3% WR)
• Yone (53.9% WR)
• Azir (53.9% WR)
• Hwei (53.2% WR)

Weak Matchups

• Fizz (45.9% WR)
• Katarina (46.7% WR)
• Talon (47.1% WR)
• Zed (47.3% WR)
• Ekko (47.4% WR)
• Aurelion Sol (47.4% WR)

Best Duo Synergies

• Darius (54.9% WR)
• Poppy (54.5% WR)
• Bel'Veth (54.3% WR)
• Qiyana (53.9% WR)
• Nocturne (53.0% WR)
• Wukong (52.9% WR)

Essential Tips

1. Delay teamfights while poking with Q and W, using strategically placed balls
2. Maximize Ultimate damage by setting up multiple spheres beforehand
3. Create pick opportunities by placing Dark Spheres in bushes and following with E stun

Advanced Combo Strategy To maximize Syndra's effectiveness, focus on ball placement and positioning before engaging. Use your abilities in sequence to create optimal damage opportunities while maintaining safe distance from assassins and dive champions.

Combat Tips

• Control neutral areas with sphere placement
• Practice sphere management for multi-target stuns
• Time your ultimates after setting up multiple spheres for maximum impact
• Use terrain to your advantage when setting up stuns

This setup is optimal for patch 15.5 and maintains effectiveness in both solo queue and coordinated play.

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