Seraphine thrives with a Sorcery/Resolve rune setup, maintaining a 50.0% win rate and 46.6% pick rate across 42,765 matches in patch 14.24.

Primary Runes (Sorcery):

• Keystone: Summon Aery
• Manaflow Band
• Transcendence
• Scorch

Secondary Runes (Resolve):

• Font of Life
• Revitalize

Strong Against:

• Swain (53.4% WR)
• Nautilus (52.9% WR)
• Alistar (52.6% WR)
• Thresh (52.0% WR)
• Pantheon (51.6% WR)
• Rakan (51.6% WR)

Weak Against:

• Shaco (46.2% WR)
• Vel'Koz (46.4% WR)
• Hwei (46.4% WR)
• Poppy (46.8% WR)
• Zyra (47.5% WR)
• Tahm Kench (47.9% WR)

Best ADC Synergies:

• Nilah (53.1% WR)
• Brand (52.8% WR)
• Xerath (52.6% WR)
• Ashe (52.6% WR)
• Vayne (52.0% WR)
• Swain (51.6% WR)

Key Tips:

1. Position for maximum impact with Ultimate (R) during jungle fights and objective contests
2. Don't rely on W's delayed healing for immediate survival
3. Conserve W during laning phase due to its long cooldown - use only when necessary

Remember that proper positioning and timing of abilities are crucial for maximizing Seraphine's support potential in teamfights and skirmishes.

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