Here's a streamlined guide for optimal Senna support runes, matchups, and tips:

Best Runes Setup (52.1% Win Rate)

• Primary: Resolve
• Secondary: Precision
• Keystone: Grasp of the Undying
• Key Runes: Font of Life, Second Wind, Revitalize
• Secondary Runes: Presence of Mind, Legend: Alacrity

Counter Matchups Weak Against:

• Shaco (43.2% WR)
• Zoe (43.8% WR)
• Lux (46.8% WR)
• LeBlanc (47.3% WR)
• Nami (47.5% WR)
• Zilean (47.7% WR)

Strong Against:

• Swain (61.9% WR)
• Brand (60.7% WR)
• Ashe (58.0% WR)
• Sylas (57.4% WR)
• Tahm Kench (57.0% WR)
• Pantheon (56.2% WR)

Best ADC Synergies

• Nilah (61.1% WR)
• Xayah (54.7% WR)
• Jhin (54.2% WR)
• Kog'Maw (54.0% WR)
• Vayne (53.9% WR)
• Draven (53.8% WR)

Essential Tips

1. Avoid using ultimate (R) mid-combo as it leaves you vulnerable and reduces DPS
2. Save E for escape/ganks rather than combat
3. Play aggressively at level 1 to establish lane dominance
4. Focus on poking and collecting souls while maintaining safe positioning
5. Coordinate ultimate timing with team engages

These stats are based on 8,179 matches from Patch 14.23.

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