Pyke Support Runes Guide

Optimal Rune Setup - 49.3% Win Rate (129,180 matches analyzed)

Primary: Domination

• Keystone: Hail of Blades
• Sudden Impact
• Eyeball Collection
• Relentless Hunter

Secondary: Resolve

• Bone Plating
• Unflinching

Strong Against:

• Zilean (53.4% WR)
• Swain (53.0% WR)
• Zyra (52.9% WR)
• Brand (52.9% WR)
• Karma (52.7% WR)
• Xerath (52.4% WR)

Weak Against:

• Maokai (45.7% WR)
• Poppy (47.0% WR)
• Sona (47.1% WR)
• Pantheon (47.6% WR)
• LeBlanc (48.0% WR)
• Nami (48.1% WR)

Best ADC Synergies:

• Xerath (59.9% WR)
• Cassiopeia (58.9% WR)
• Heimerdinger (57.6% WR)
• Karthus (56.9% WR)
• Veigar (55.7% WR)
• Swain (55.0% WR)

Key Tips:

1. Track enemy cooldowns, especially Flash, before using your Ultimate (R)
2. Wait for enemies to use mobility spells before initiating with Hook (Q)
3. Utilize Pyke's strong roaming potential to assist mid and jungle

Expert Combos:

• Q > E > Auto > R (Basic execution combo)
• E > Flash > Q > R (Surprise engage)
• W > E > Q > R (Stealth initiation)
• Q > Flash > E > R (Hook flash combo)

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