Grasp of the Undying remains the optimal keystone rune for Tahm Kench Mid in patch 15.4, maintaining a 50.2% win rate across 227 matches. The most effective rune combination pairs Resolve (primary) with Precision (secondary).

Primary Runes (Resolve):

• Keystone: Grasp of the Undying
• Shield Bash
• Second Wind
• Revitalize

Secondary Runes (Precision):

• Triumph
• Legend: Alacrity

Strong Matchups:

• Mel (60.3% WR)
• Xerath (55.8% WR)
• Neeko (54.2% WR)
• Shaco (53.9% WR)
• Blitzcrank (53.5% WR)
• Senna (52.9% WR)

Weak Matchups:

• Sona (37.7% WR)
• Taric (42.4% WR)
• Elise (43.1% WR)
• Fiddlesticks (43.4% WR)
• Vel'Koz (44.0% WR)
• Zilean (44.5% WR)

Best Synergies:

• Swain (57.7% WR)
• Vayne (52.3% WR)
• Jinx (51.7% WR)
• Smolder (51.7% WR)
• Sivir (51.1% WR)
• Tristana (50.9% WR)

This optimized rune setup enhances Tahm Kench's lane sustain and trading potential while providing crucial late-game scaling through Precision secondaries. The combination particularly excels in extended trades and skirmishes, leveraging Tahm Kench's natural tankiness and sustained damage output.

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