Nautilus Support Best Runes & Matchups Patch 15.4

Nautilus Support Best Runes & Matchups Patch 15.4

By Marcus Chen

February 25, 2025 at 03:53 PM

Nautilus Support Runes Guide

Optimal Rune Setup (Patch 15.4):

  • Primary Tree: Resolve
  • Secondary Tree: Inspiration
  • Current Win Rate: 48.9%
  • Pick Rate: 65.1% (based on 29,779 matches)

Best Primary Runes (Resolve):

  • Keystone: Aftershock
  • Shield Bash
  • Second Wind
  • Overgrowth

Best Secondary Runes (Inspiration):

  • Hextech Flashtraption
  • Biscuit Delivery

Strong Against:

  • Yuumi (54.5% WR)
  • Mel (53.5% WR)
  • Zilean (53.2% WR)
  • LeBlanc (52.8% WR)
  • Elise (52.5% WR)
  • Pantheon (52.5% WR)

Weak Against:

  • Taric (36.7% WR)
  • Renata Glasc (42.7% WR)
  • Rell (43.3% WR)
  • Tahm Kench (43.9% WR)
  • Bard (45.0% WR)
  • Neeko (45.3% WR)

Best ADC Synergies:

  • Samira (52.1% WR)
  • Yasuo (51.4% WR)
  • Sivir (51.2% WR)
  • Kog'Maw (50.9% WR)
  • Nilah (50.8% WR)
  • Xayah (50.7% WR)

Pro Tips:

  1. Save your Q (hook) until enemies use their escape abilities or misposition
  2. Use Q to catch overextended enemies during tower sieges
  3. Utilize your strong CC for roaming opportunities after recalls

Essential Combos:

  • Available in-game through the combos menu

For optimal performance, coordinate engages with your ADC and time your roams to support other lanes when possible.

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