Galio's Optimal Runes Guide for Mid Lane

Aftershock remains the dominant keystone choice for Galio mid in patch 15.4, maintaining a 49.8% win rate across 33,548 matches with a 48.2% pick rate.

Primary Runes (Resolve):

• Keystone: Aftershock
• Demolish
• Second Wind
• Overgrowth

Secondary Runes (Sorcery):

• Manaflow Band
• Transcendence

Strong Matchups:

• Diana (55.7% WR)
• Katarina (54.4% WR)
• Malzahar (54.3% WR)
• Mel (54.0% WR)
• Akali (53.5% WR)
• Sylas (53.1% WR)

Weak Matchups:

• Swain (42.9% WR)
• Anivia (45.8% WR)
• Ahri (46.2% WR)
• Veigar (46.3% WR)
• Vel'Koz (46.5% WR)
• Karma (46.9% WR)

Best Duo Synergies:

• Amumu (55.2% WR)
• Bel'Veth (53.7% WR)
• Warwick (53.3% WR)
• Master Yi (53.0% WR)
• Darius (53.0% WR)
• Rengar (52.9% WR)

Essential Tips:

1. Play cautiously after level 6 as your ultimate is utility-focused
2. Set up ganks by maintaining wave control near your tower
3. Before roaming with ultimate, clear wave using Q + E combo followed by empowered auto-attack

This build guide provides optimal rune choices while maximizing Galio's strengths in the mid lane. Adapt your playstyle based on matchups and team composition for best results.

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