Kassadin's optimal rune setup for Top lane in patch 14.24 features Fleet Footwork as the keystone, achieving a 52.3% win rate across 176 matches.

Primary Runes (Precision):

• Fleet Footwork
• Presence of Mind
• Legend: Haste
• Cut Down

Secondary Runes (Resolve):

• Second Wind
• Overgrowth

Strong Against:

• Lux (59.5% WR)
• Swain (58.9% WR)
• Tristana (56.8% WR)
• Ekko (54.6% WR)
• Katarina (54.3% WR)
• Annie (54.0% WR)

Weak Against:

• Vel'Koz (40.9% WR)
• Diana (44.9% WR)
• Vladimir (44.9% WR)
• Naafiri (45.3% WR)
• Anivia (45.9% WR)
• Irelia (46.2% WR)

Best Jungle Synergies:

• Skarner (55.3% WR)
• Lillia (54.4% WR)
• Ekko (54.3% WR)
• Shaco (53.7% WR)
• Kha'Zix (53.2% WR)
• Hecarim (53.1% WR)

Key Tips:

1. Prioritize safe farming and health management during early laning phase
2. Focus on personal scaling until level 16 power spike
3. Trade only when enemy key abilities are on cooldown post-level 6
4. Use Ultimate (R) aggressively only when enemies lack immediate counterplay options

Effective trading patterns rely on proper ability sequencing and cooldown management, especially after reaching level 6.

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