Kalista's most effective rune setup combines Precision and Domination trees, achieving a 48.1% win rate with an 85.0% pick rate across 16,700 matches.

Primary Tree (Precision)

• Keystone: Lethal Tempo
• Triumph
• Legend: Alacrity
• Cut Down

Secondary Tree (Domination)

• Sudden Impact
• Treasure Hunter

Key Matchups

Unfavorable Matchups:

• Swain (41.5% WR)
• Miss Fortune (41.7% WR)
• Smolder (42.7% WR)
• Aphelios (43.8% WR)
• Corki (44.3% WR)
• Jinx (45.3% WR)

Favorable Matchups:

• Mel (55.8% WR)
• Zeri (52.2% WR)
• Varus (51.7% WR)
• Jhin (50.7% WR)
• Kai'Sa (50.5% WR)
• Ezreal (49.9% WR)

Best Support Synergies:

• Senna (56.0% WR)
• Taric (53.5% WR)
• Thresh (51.6% WR)
• Janna (51.0% WR)
• Swain (51.0% WR)
• Maokai (50.6% WR)

Essential Tips:

1. Use Ultimate (R) for engagement or saving allies
2. Hold Rend (E) until skirmish completion to maximize stack potential
3. Scout river vision efficiently with Sentinel (W), maximizing range for optimal information gathering

This strategic setup ensures optimal performance in bot lane while maintaining flexibility against various matchups.

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