Precision and Inspiration represent the optimal rune choices for Varus in patch 14.23, maintaining a 49.6% win rate with a 51.1% pick rate across 69,083 matches.

Primary Runes (Precision):

• Lethal Tempo (Keystone)
• Triumph
• Legend: Alacrity
• Coup de Grace

Secondary Runes (Inspiration):

• Biscuit Delivery
• Cosmic Insight

Strong Matchups:

• Kalista (52.5% WR)
• Twitch (52.2% WR)
• Samira (51.5% WR)
• Swain (51.2% WR)
• Kai'Sa (51.0% WR)
• Smolder (50.9% WR)

Weak Matchups:

• Hwei (45.6% WR)
• Kog'Maw (46.6% WR)
• Seraphine (47.0% WR)
• Ziggs (47.4% WR)
• Sivir (47.4% WR)
• Nilah (47.9% WR)

Best Support Synergies:

• Elise (59.2% WR)
• Galio (54.9% WR)
• Camille (53.9% WR)
• Taric (53.7% WR)
• Shen (53.3% WR)
• Amumu (52.8% WR)

Key Tips:

1. Harass enemies with E and Q before engaging in fights
2. Use Q to poke during pre-teamfight phase
3. Cast R to catch overextended enemies
4. Stay close to your support in late game to avoid assassins
5. Focus on positioning and team coordination

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