Best Twitch Runes for Bot Lane in Patch 15.5

Best Twitch Runes for Bot Lane in Patch 15.5

By Marcus Chen

March 17, 2025 at 05:48 AM

Runes for Twitch Bot Lane (Patch 15.5)

Optimal Rune Setup: Precision + Sorcery

  • Win Rate: 50.2%
  • Pick Rate: 52.1%
  • Based on 33,821 matches

Primary Tree (Precision):

  • Keystone: Lethal Tempo
  • Presence of Mind
  • Legend: Alacrity
  • Coup de Grace

Secondary Tree (Sorcery):

  • Axiom Arcanist
  • Gathering Storm

Strong Against:

  • Sivir (55.4% WR)
  • Jhin (54.0% WR)
  • Aphelios (53.3% WR)
  • Varus (52.7% WR)
  • Zeri (52.2% WR)
  • Kalista (52.2% WR)

Weak Against:

  • Yasuo (40.6% WR)
  • Nilah (45.1% WR)
  • Seraphine (45.8% WR)
  • Corki (47.6% WR)
  • Tristana (47.7% WR)
  • Vayne (48.1% WR)

Best Support Synergies:

  • Taric (55.1% WR)
  • Pantheon (53.8% WR)
  • Lulu (53.5% WR)
  • Zilean (53.1% WR)
  • Leona (52.6% WR)
  • Braum (52.5% WR)

Key Tips:

  1. Position your Ultimate (R) to hit multiple enemies for maximum damage output
  2. Play safely in early game until first item completion
  3. Prioritize extended trades to maximize passive damage potential

These runes and statistics are optimized for ADC role in Bot lane. Adjust your playstyle based on matchups and team composition.

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