Pyke's optimal support runes in patch 14.24 focus on maximizing his aggressive playstyle and roaming potential. The most successful combination (49.3% win rate, 66.1% pick rate across 130,218 matches) uses Domination primary and Resolve secondary.

Primary Runes (Domination):

• Keystone: Hail of Blades
• Sudden Impact
• Eyeball Collection
• Relentless Hunter

Secondary Runes (Resolve):

• Bone Plating
• Unflinching

Strong Matchups (52%+ win rate):

• Zilean (53.2%)
• Swain (53.0%)
• Zyra (52.9%)
• Brand (52.7%)
• Karma (52.6%)
• Xerath (52.4%)

Weak Matchups (Sub-48% win rate):

• Maokai (45.6%)
• Poppy (47.0%)
• Sona (47.3%)
• Pantheon (47.6%)
• LeBlanc (47.9%)
• Nami (48.2%)

Best ADC Synergies:

• Xerath (59.7%)
• Cassiopeia (59.2%)
• Heimerdinger (57.5%)
• Karthus (57.0%)
• Veigar (55.2%)
• Swain (55.1%)

Key Tips:

1. Track enemy cooldowns, especially Flash, before using your Ultimate (R)
2. Wait for enemies to use mobility abilities before attempting hooks (Q)
3. Utilize Pyke's strong roaming potential to impact other lanes

These runes optimize Pyke's ability to engage, secure kills, and rotate around the map while maintaining sufficient durability for teamfights.

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