Karthus Jungle Runes Guide

Dark Harvest is the optimal keystone for Karthus Jungle, boasting a 52.7% win rate in patch 15.5 across 20,531 matches. This build has a significant 61.0% pick rate among players.

Primary Runes (Domination):

• Dark Harvest
• Cheap Shot
• Sixth Sense
• Treasure Hunter

Secondary Runes (Precision):

• Triumph
• Last Stand

Strong Matchups:

• Zyra (55.6% WR)
• Vi (53.9% WR)
• Elise (53.9% WR)
• Viego (53.5% WR)
• Amumu (53.2% WR)

Weak Matchups:

• Yorick (43.2% WR)
• Dr. Mundo (44.1% WR)
• Nunu & Willump (44.7% WR)
• Shyvana (45.5% WR)
• Darius (45.6% WR)

Best Synergies:

• Ambessa (56.9% WR)
• Kled (56.8% WR)
• Annie (56.6% WR)
• Pantheon (56.5% WR)
• LeBlanc (55.9% WR)

Essential Tips:

1. Focus ganks on overextended, low-health lanes due to limited ganking potential
2. Toggle E ability on/off while farming jungle camps to maximize damage while conserving mana
3. Monitor minimap constantly to secure kills on low-health enemies with ultimate (R)

Related Champions:

• Average difficulty: Similar playstyle champions
• Severe difficulty: More challenging alternatives
• Severe difficulty: Complex mechanics required
• Severe difficulty: High skill ceiling options

The information is based on current patch data and professional player builds, regularly updated to maintain accuracy.

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