Kalista Runes Guide for Patch 15.4

Precision (Primary) + Domination (Secondary) maintains a 48.2% win rate with 84.9% pick rate across 17,299 matches.

Optimal Rune Setup:

• Primary (Precision):

  • Keystone: Lethal Tempo
  • Triumph
  • Legend: Alacrity
  • Cut Down

• Secondary (Domination):

  • Sudden Impact
  • Treasure Hunter

Strong Against:

• Mel (56.3% WR)
• Zeri (52.4% WR)
• Varus (51.7% WR)
• Kai'Sa (50.6% WR)
• Jhin (50.6% WR)
• Ezreal (50.2% WR)

Weak Against:

• Swain (40.0% WR)
• Miss Fortune (42.0% WR)
• Smolder (42.4% WR)
• Aphelios (43.7% WR)
• Corki (44.7% WR)
• Nilah (45.1% WR)

Best Support Synergies:

• Senna (55.2% WR)
• Taric (52.7% WR)
• Thresh (51.7% WR)
• Yuumi (51.2% WR)
• Swain (51.0% WR)
• Janna (50.7% WR)

Key Tips:

1. Use Ultimate (R) for engagement or saving your support
2. Hold Rend (E) until skirmish completion to maximize stack damage
3. Utilize Sentinel (W) for maximum river vision coverage

This build optimization is based on current patch data and high-elo gameplay analysis.

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