Kai'Sa's optimal runes for Top lane focus on maximizing her damage output and early game sustenance. In patch 15.4, her build achieves a 43.2% win rate with a 51.2% pick rate across 384 matches.

Primary Rune Path (Precision):

• Keystone: Lethal Tempo
• Triumph
• Legend: Alacrity
• Cut Down

Secondary Rune Path (Inspiration):

• Magical Footwear
• Biscuit Delivery

Strongest Matchups:

• Mel (54.3% WR)
• Ziggs (51.2% WR)
• Jhin (51.1% WR)
• Lucian (50.7% WR)
• Ezreal (50.6% WR)
• Kalista (49.9% WR)

Challenging Matchups:

• Kog'Maw (42.3% WR)
• Nilah (43.7% WR)
• Aphelios (44.1% WR)
• Vayne (45.5% WR)
• Jinx (46.0% WR)
• Yasuo (46.3% WR)

Best Support Synergies:

• Sona (52.6% WR)
• Vel'Koz (52.0% WR)
• Amumu (51.9% WR)
• LeBlanc (51.6% WR)
• Poppy (51.4% WR)
• Zoe (51.0% WR)

This build optimizes Kai'Sa's ability to trade effectively in lane while maintaining sustained damage output in team fights. The combination of Precision and Inspiration runes provides a balance of damage and utility, making her a versatile pick in the top lane.

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