Let's focus on providing clear, valuable information about Kai'Sa and her optimal runes setup.

Current patch statistics show Kai'Sa with Precision/Inspiration runes maintains a 48.3% win rate with a 74.9% pick rate (based on 170,236 matches).

Primary Runes (Precision):

• Keystone: Lethal Tempo
• Triumph
• Legend: Alacrity
• Cut Down

Secondary Runes (Inspiration):

• Magical Footwear
• Biscuit Delivery

Key Matchups: Strong Against:

• Mel (51.4% WR)
• Jhin (50.3% WR)
• Ezreal (50.2% WR)

Weak Against:

• Nilah (42.6% WR)
• Kog'Maw (42.9% WR)
• Swain (43.9% WR)

Best Support Synergies:

• Fiddlesticks (53.0% WR)
• Amumu (52.4% WR)
• Braum (50.9% WR)

Essential Tips:

1. Build mixed damage items (AD, AP, and attack speed) to maximize evolved abilities
2. Use ultimate (R) strategically for repositioning and shield protection in teamfights
3. Target isolated enemies with Q for maximum damage output

Combat Tips:

• Prioritize isolated Q hits for maximum single-target damage
• Use ultimate defensively to reposition in teamfights
• Combine AD and AP items to unlock ability evolutions
• Position aggressively when supported by CC-heavy champions like Amumu or Fiddlesticks

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