Zoe's optimal Mid lane runes for patch 14.23 prioritize burst damage and mana sustain, achieving a 49.6% win rate across 6,693 matches.

Primary Runes (Domination):

• Keystone: Electrocute
• Taste of Blood
• Eyeball Collection
• Treasure Hunter

Secondary Runes (Sorcery):

• Manaflow Band
• Transcendence

Strong Matchups (Win Rate):

• Taliyah (56.8%)
• Jayce (55.6%)
• Diana (55.4%)
• Cassiopeia (55.1%)
• Irelia (55.0%)
• Azir (54.7%)

Weak Matchups (Win Rate):

• Naafiri (35.6%)
• Talon (44.2%)
• Anivia (44.7%)
• Aurelion Sol (44.9%)
• Akshan (45.3%)
• Ekko (45.3%)

Best Jungle Synergies:

• Master Yi (57.9%)
• Warwick (54.4%)
• Ekko (53.8%)
• Diana (53.7%)
• Jarvan IV (53.2%)
• Graves (52.5%)

Key Tips:

1. Use terrain to extend E travel distance
2. Poke with Q and look for E picks before teamfights
3. Replace W spells by walking over new Summoner Spells or active items

These runes optimize Zoe's burst damage potential while maintaining sufficient mana for extended lane presence and roaming opportunities.

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