Cassiopeia's optimal runes for Top lane in patch 14.23 combine Precision and Sorcery trees, achieving a 53.4% win rate across 15,099 matches.

Primary Tree (Precision):

• Keystone: Conqueror
• Presence of Mind
• Legend: Haste
• Cut Down

Secondary Tree (Sorcery):

• Manaflow Band
• Transcendence

Strong Against:

• Smolder (62.5% WR)
• Corki (57.4% WR)
• Swain (56.4% WR)
• Yone (56.0% WR)
• Yasuo (55.7% WR)
• Kassadin (55.7% WR)

Weak Against:

• Vel'Koz (46.5% WR)
• Syndra (46.6% WR)
• Qiyana (46.7% WR)
• Naafiri (46.8% WR)
• Zoe (47.1% WR)
• Anivia (47.3% WR)

Best Jungle Synergies:

• Rammus (58.7% WR)
• Rek'Sai (57.2% WR)
• Ekko (55.4% WR)
• Bel'Veth (55.3% WR)
• Diana (55.2% WR)
• Xin Zhao (54.7% WR)

Essential Tips:

1. Monitor mana consumption during early trades
2. Only engage in trades after landing Q ability
3. Exploit strong level 2 all-in potential against squishier champions
4. Follow up successful Q hits with multiple E abilities for optimal damage

Note: Play aggressively when ahead but remain mindful of mana management throughout all stages of the game.

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